The most frequently reported side effects of NAD+ injections are related to the injection process itself. Patients commonly experience localized reactions at the injection site, including pain, redness, swelling, or bruising. Some individuals report a burning or stinging sensation during injection. Systemic effects may include fatigue, nausea, or headache following treatment. A subset of patients may experience flushing or warmth, similar to niacin flush, due to NAD+'s relationship with vitamin B3 metabolism. Additionally, some individuals report feeling energized or experiencing difficulty sleeping if injections are administered later in the day, suggesting that the timing of administration may influence individual responses. Other side effects may include dizziness, changes in blood pressure, or gastrointestinal upset such as stomach discomfort or loose stools. Some patients report mood changes or heightened emotional sensitivity in the hours following treatment. Serious adverse reactions may include severe allergic reactions, persistent injection site complications, or unexpected cardiovascular symptoms. Patients should immediately report any concerning symptoms to their healthcare provider and seek emergency medical attention for severe reactions such as difficulty breathing, chest pain, or signs of severe allergic reaction. See the Important Safety Information for a full list of potential side effects.
This article is for informational purposes only and does not constitute medical advice. The information contained in this article is not a substitute for and should never be relied upon for professional medical advice. Always talk to your provider about the risks and benefits of any treatment.
