Take Sertraline tablets exactly as prescribed. Sertraline tablets may be taken with or without food. If you miss a dose of Sertraline tablets, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Sertraline tablets at the same time. If you take too many Sertraline tablets, call your healthcare provider or poison control center right away, or get emergency treatment.