The most common side effects of Semaglutide involve your digestion and gastrointestinal tract. Burping, bloating, gas, heartburn, nausea, vomiting, upset stomach, stomach pain, constipation, diarrhea, or symptoms that feel like a stomach flu may occur. Other common side effects may include headache, dizziness, tiredness, and low blood sugar levels in people who have diabetes. For a full list of the possible side effects of Semaglutide, including the less common but more serious side effects, look at the patient safety information and the Semaglutide package information.